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Publication Title | Method to Produce Medical Cannabis Extract for Treatment of Pediatric

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Method to Produce Medical Cannabis Extract for Treatment of Pediatric

Epilepsy 1-12-16

Recently, in December of 2015, THC Safety, Inc. conducted a presentation in Honolulu Hawaii. The course was titled Cannabis Concentrate Production Technology. The objective of the course was to provide the attendees with an understanding of the technology, processes and safety concerns associated with commercial extraction of cannabis. One of the attendees was the mother of a child that suffered from epileptic seizures that resulted in convulsions. Even though home-based extraction is not our business, we decided to write this paper to assist people like the mother, Jari, in creating an effective home-based pediatric cannabis extract for prevention of convulsions. The first task was to conduct research of the scientific literature to identify the cannabinoid profile and dose that was recommended, in addition to taking into consideration Jari’s personal findings that an approximate 1:1 THC:CBD mix was efficient at controlling night time seizures.

From different sources, we found that the recommended THC:CBD ratio varied from about 1:1 – 1:15. We would recommend starting with a 1:6 mixture. Please note that the author is not a physician, but a chemist and a Certified Industrial Hygienist; therefore if possible we recommend that you get advice from an MD, but unfortunately for pediatric cases this may be almost impossible. I strongly recommend that you review the references that are listed in this document. It is often recommended that the dose gets split into two administrations per day (BID).

Here are some results:

Oral cannabidiol, 200–300 mg/day for 8–18 weeks; n = 8 patients; placebo: seven patients.

Efficacy: Of the eight patients receiving cannabidiol, four subjects remained virtually convulsion-free for the duration of the study and three other subjects exhibited a clinical improvement.

Note: The sublingual spray (under the tongue).... compared to the oral administration, reduces the first-pass metabolism, thus increasing the bioavailability of the drug and allowing a greater dose-titration.

Note: Epidiolex® A liquid formulation of pure plant-derived Cannabidiol (CBD), as a treatment for various orphan pediatric epilepsy syndromes...98% oil-based CBD extract.. daily dose was gradually increased by 2-5mg/kg increments at 1-2 intervals until intolerance occurred or a maximum dose of 25 mg/kg/day.

In order to get a the desired THC:CBD ratio, you must start with whole plant material that has the ratio that you are looking for. The ratio in the extract will be mirrored by the ratio in the plant material, so select an appropriate cannabis breed that has the ratio desired. For example, the following Tikun Olam breeds have the following specified cannabinoid profile:

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