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Publication Title | Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

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Rev Bras Psiquiatr. 2012;34(Supl1):S104-S117

ARTICLE

Revista Brasileira de Psiquiatria

Psychiatry

Of cial Journal of the Brazilian Psychiatric Association Volume 34 • Supplement 1 • June/2012

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

Alexandre Rafael de Mello Schier,1 Natalia Pinho de Oliveira Ribeiro,1 Adriana Cardoso de Oliveira e Silva,1,2,4 Jaime Eduardo Cecilio Hallak,3,4 José Alexandre S. Crippa,3,4 Antonio E. Nardi,1,4 Antonio Waldo Zuardi3,4

1 Laboratory of Panic and Respiration, Institute of Psychiatry (IPUB), Universidade Federal do Rio de Janeiro (UFRJ), Brazil 2 Universidade Federal Fluminense, Brazil

3 Department of Neuroscience and Behavioral Sciences, Faculdade de Medicina de Ribeirão Preto,

Universidade de São Paulo, Brazil

4 Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (National Institute for Translational Medicine; INCT-TM), Brazil

Received on March 2, 2011; accepted on December 18, 2011

DESCRIPTORS

Cannabidiol; Cannabis sativa; Anxiolytics; Anxiety disorders.

Abstract

Objectives: To review and describe studies of the non-psychotomimetic constituent of Cannabis sativa, cannabidiol (CBD), as an anxiolytic drug and discuss its possible mechanisms of action. Method: The articles selected for the review were identi ed through searches in English, Portuguese, and Spanish in the electronic databases ISI Web of Knowledge, SciELO, PubMed, and PsycINFO, combining the search terms “cannabidiol and anxiolytic”, “cannabidiol and anxiolytic- like”, and “cannabidiol and anxiety”. The reference lists of the publications included, review articles, and book chapters were handsearched for additional references. Experimental animal and human studies were included, with no time restraints. Results: Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder. Conclusion: Future clinical trials involving patients with different anxiety disorders are warranted, especially of panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorders. The adequate therapeutic window of CBD and the precise mechanisms involved in its anxiolytic action remain to be determined.

Corresponding author: Alexandre Rafael de Mello Schier; E-mail: alexschier@hotmail.com 1516-4446 - ©2012 Elsevier Editora Ltda. All rights reserved.

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